There are only so many antiretroviral and some people have HIV that is resistant to many of the cocktails already. So now you have three again and it works, till the next failure cycle. Three antiretrovirals do this but eventually one of those three will always fail and you doctor simply switches your medicines. It was found two or less drugs would not keep the virus at bay long enough to help much. This will always happen,ĪIDS meds consist of at least three different drugs. The virus will mutate and overcome the meds. First of all AIDS cocktails will always fail.